Located 5 minutes' stroll from Piazza Anfiteatro Entrance & Ticket Office, Domus Serena Pompei hotel is within a 5-minute drive of Campana. The bed & breakfast offers a private parking garage for EUR 10 per day nearby.

Pompei centre can be reached within 10 minutes' walk. Temple of Isis is within close distance of this Pompei hotel, while Capodichino airport is 30 km from it. The accommodation is centrally located, 5 minutes on foot from Shrine of the Virgin of the Rosary of Pompei. Domus Serena hotel is also a minute's walk from Pompei Piazza Anfiteatro bus stop.

The rooms at the property feature a work desk, along with sound-proofed windows for guests' convenience. They have kitchen facilities, such as a microwave, an electric kettle, and a refrigerator. Featuring a bidet, a walk-in shower, and a separate toilet, the bathrooms also come with a hairdryer and bath sheets.

The Domus Serena offers a buffet breakfast daily. Guests can enjoy Italian cuisine at Zi' Caterina, situated only 5 minutes' walk from this property.